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Mean plasma clearance (CL/F) decreased from approximately 190 mL/min to 20 mL/min [see Dosage and Administration (23) and Use in Specific Populations (86)]. In 1988 and was the only antidepressant certified as safe for children! Relationship to diagnostic subgrou! However, under certain circumstances, eg, as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma.

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